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In a controlled crossover feeding study, a high-GI meal selectively increased activation in reward and craving regions four hours postprandially compared with an isocaloric low-GI meal, independent of palatability [26]

10.1096/fj.14-265983 FASEB J

Desensitization and Receptor Trafficking Most agonist-activated GPCRs undergo rapid desensitization through a coordinated two-step process: first, phosphorylation of the receptor by GRKs, and second, recruitment of -arrestins to these phosphorylated sites, which sterically block further G-protein coupling [54]