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Although the trial did not show a significant advantage in reducing cardiovascular events [6], or hospitalizations, it provided insights into liraglutides safety and tolerability in this patient population [6]

Although a decrease in systolic blood pressure is observed with GLP-1 RAs (ranging from 1.84 mmHg [95% CI 3.48 to 0.20] to 4.60 mmHg [95% CI 7.18 to 2.03]) [113], the possibility of requiring adjustment of simultaneous diuretic treatment should be considered
Tirzepatide 15 mg was also associated with higher incidence of vomiting (OR 5.50 [95% CI 2.40, 12.59], I 2 0%) and diarrhoea (OR 3.31 [95% CI 1.40, 7.85], I 2 52%), while more participants receiving tirzepatide 10 mg experienced vomiting (OR 2.98 [95% CI 1.13, 7.80], I 2 0%) (Table 2)
M., Chen, Y., ONeill, E

These mechanisms are specified below