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[DOI] [PMC free article] [PubMed] [Google Scholar] 34.Nauck MA, Muus Ghorbani ML, Kreiner E, Saevereid HA, Buse JB, LEADER Publication Committee on behalf of the LEADER Trial Investigators Effects of liraglutide compared with placebo on events of acute gallbladder or biliary disease in patients with type 2 diabetes at high risk for cardiovascular events in the LEADER randomized trial

The therapeutic relevance of brain GLP-1 activity has expanded considerably with the widespread use of GLP-1 receptor agonists such as semaglutide (Ozempic, Wegovy) and liraglutide (Victoza, Saxenda)

Non-invasive treatments using radiofrequency, ultrasound, or laser technology can provide modest skin tightening for patients with mild to moderate looseness

In addition, strong commercialization strategies and broad reimbursement coverage have increased accessibility

Given that GLP-1 biology is complex and may involve several parallel mechanisms with or without transmembrane receptors (31) and distinct metabolites (32), we chose to next focus on the direct actions of the single metabolite GLP-1(2836) using in-depth in vitro studies into its cellular and molecular actions