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However, they also increase analytical complexity and require highly accurate analytical techniques

Awareness prevents these issues

doi: 10.1111/j.1742-481X.2012.01022.x 182 WolakMStaszewskaTJuszczakMGadyszyskaMBojanowskaE
It can matter but mostly within limits

Figure 2 In addition, the inhibitory effects of exendin-4 on MG-induced mRNA expressions of various mitochondrial markers (COX5a, MCU, PGC1, DRP1), and mRNA and protein expressions of pro-apoptotic markers (Bad and Bax) were blocked by ddA ( Figures 2EG )