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how were glp 1 agonists discovered Timeline of GLP-1 discovery and clinical development. (a) Key events in Evolution of GLP-1 receptor agonists
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Even the 4mg dose saw 61% and 44% losing 15 and 20% body weight respectively

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A healthy gut microbiome with diversity produces short-chain fatty acids, causing GLP-1 release

GIP, gastric inhibitory polypeptide

Amylin, which is also co-secreted with insulin, also affects glucagon release from the -cells
