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The SURMOUNT 5 trial, published in the New England Journal of Medicine , delivered the first true head to head comparison of tirzepatide (Zepbound/Mounjaro) versus semaglutide (Wegovy/Ozempic)

Perhaps more impressively, 89-93% of participants achieved less than 5% liver fat content, which is the threshold for being considered free of fatty liver disease

Electrophysiological examinations indicated a significant reduction in paw withdrawal frequency of the left limb following exendin-4 treatment, correlating with effective pain relief [68]

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