tirzepatide once weekly for the treatment of obesity journal club VisualAbstract: Tirzepatide for Obesity: Highlights from
Description
The adipocyte is an important site of triglyceride metabolism [29] and is unique in its expression of the GIPR and not the GLP-1R
Severe hypoglycemia and risks of vascular events and death
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The co-primary endpoints, percent change in body weight from baseline and proportion of patients achieving 5% weight loss, were identical to those of SURMOUNT-1, as were the two estimands: the TRE (which included all patients who were randomized) and the efficacy estimand (which included randomized patients who remained on the study treatment for the entire efficacy assessment duration of the trial)
While absorption characteristics differ, many patients achieve comparable weight loss results with the added convenience of needle-free daily administration
