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This discouraged researchers from pursuing GIP as a therapeutic target

Retatrutide is being developed for the treatment of obesity and type 2 diabetes

These benefits, along with already widespread use and generally good tolerability profile, have piqued interest in the potential benefit of SGLT2i and GLP1-RA in patients with rheumatologic conditions, who are at higher risk of cardiovascular and renal complications

Either approach works

Effect of pioglitazone on pancreatic beta-cell function and diabetes risk in Hispanic women with prior gestational diabetes
