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However, DPP-4 inhibitors have not reduced the risk of major adverse cardiovascular events, possibly because potentiation of SDF-1 enhances plaque growth and instability, activates deleterious neurohormonal mechanisms, and promotes cardiac inflammation and fibrosis

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Butyrate possesses unique cell-signalling properties which have shown effects of decreasing insulin resistance in humans, increasing GLP1 production by intestinal cells & the liver, while also sensitizing our body to the effects of GLP-1 [3]

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