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The FDA approved Vyjuvek in May 2023 and, in September 2025, the US agency cleared a label update expanding the eligible Vyjuvek patient population to include DEB patients from birth

Additionally, patients with diabetic retinopathy should proceed with caution, particularly when using subcutaneous semaglutide, as some trials have reported a higher incidence of retinopathy-related complications

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Some expenses are not HSA/FSA eligible even with a prescription, such as shipping fees, late fees, travel costs, and non-prescription supplements