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Clinical trials show that gastrointestinal side effects, including diarrhea, occur in approximately 20% of semaglutide users and typically improve within the first 812 weeks of treatment

Gradual titration improves tolerability for most patients

Recently, the FDA issued black-box warnings, its most prominent drug safety statements, for esketamine, 1 which is indicated for treatment-resistant depression, and the Z-drugs, which are indicated for insomnia 2 ( Table 1 )

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