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We previously performed emulation target trials and cohort studies using the TriNetX platform to examine the association of GLP-1RAs, including semaglutide, with Alzheimer disease, 23 substance use disorders, 24,25,26,27 suicidal ideation, 28 and cancers

These data, combined with an automated analysis of whole-brain c-Fos activity showing sites with and without direct compound access, support a model in which semaglutide regulates BW by directly targeting independent brain regions

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Biochem Biophys Res Commun 2009;390:613-8.ArticlePubMed 88

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