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Supporting this possibility, preclinical studies have reported that setmelanotide can effectively restore MC4R activity in obese animal models harboring LOF MC4R variants, thereby reducing food intake and increasing total energy expenditure, which results in significant weight loss

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As a GLP-1 receptor agonist, semaglutide GLP-1 mimics the natural hormone glucagon-like peptide-1, crucial in appetite regulation

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