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Description
Active-Controlled Study vs Glipizide in Combination with Metformin The efficacy of JANUVIA was evaluated in a 52-week, double-blind, glipizide-controlled noninferiority trial in patients with type 2 diabetes

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Genetic engineering opened up a new way to manufacture human proteins previously difficult to obtain in large quantities

What changed: after the FDA declared the semaglutide shortage resolved, the broad, shortage-era compounding largely ended, with enforcement timelines through 2025

Document the timing relative to dose changes
