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423 Furthermore, the study emphasized that neurons in specific brain regions, such as the hindbrain and hypothalamus, co-express GLP-1R along with 1-adrenergic and -opioid receptors, suggesting a localized mechanism within the CNS that could coordinate peripheral anti-inflammatory responses

Hypoxanthine The purine nucleobase hypoxanthine, as an available substrate for efficient purine nucleotide biogenesis, is a significant host-microbial co-metabolite (Mars et al., 2020)