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Yet the soaring enthusiasm for so-called glucagon-like peptide-1 receptor agonists, first approved in 2005 , overshadows an array of risks related to their off-label use
Navarro, M
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Furthermore, elevated methylation levels of peroxisome proliferator-activated receptor gamma (PPARG) suppress its transcriptional activity, impairing adipocyte differentiation and glucose homeostasis, which contributes to the development of obesity and metabolic syndrome in PCOS patients (51)
For side effects including GI symptoms that may worsen with alcohol, see GLP-1 side effects
