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These include pancreatitis (rare but reported in clinical trials and post-marketing surveillance), gallbladder disease, and acute kidney injury (particularly in the setting of severe dehydration from gastrointestinal effects)

The coefficient of variation of intra-assay was below 10%

While acknowledging that pancreatitis is rare, on Thursday the Medicines and Healthcare products Regulatory Agency (MHRA) updated its guidance, after an increase in reports of acute pancreatitis to the agencys yellow card scheme, which monitors any adverse reactions to medications and medical devices in the UK

Their use was associated with reduced mortality and improved cardiovascular and kidney outcomes in matched control studies

And roughly half of people worldwide have a headache disorder, including migraine and tension-type headache