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In the UK, reconstitution of injectable medications like tirzepatide must only be performed by qualified healthcare professionals in appropriate aseptic facilities following validated procedures

Spironolactone has a short half-life (~1-2 days) and androgens return to baseline within weeks of stopping
These risks need to be considered together as part of an individual patient profile. Real-world data at a global scale A key strength of the study is its scale and approach

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Rose SR, Brown RS, Foley T, et al
