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Of the 24 participants who completed the trial, the maximum tolerated dose of semaglutide was 0.25 mg in two (8.3%) participants, 0.5 mg in six (25.0%) participants and 1 mg in 16 (66.7%) participants

This represents an exposure of about 2- and 6-times a 2000 mg clinical dose based on body surface area (mg/m2) for rats and rabbits, respectively

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The Triple Receptor Mechanism GLP-1 activation helps reduce appetite and slows stomach emptying

Measuring small doses requires precision