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Studies on lipohypertrophy in insulin-dependent diabetic patients (who inject far more frequently than once-weekly semaglutide users) consistently show that tissue damage from repeated injection in the same site causes clinically meaningful absorption problems

The goal is consistent: deposit the peptide in the subcutaneous fat layer, not in the dermis above or the muscle below

While originally developed for diabetes, several have been FDA-approved for weight loss as well

Last but definitely not least, inform your dentist as soon as possible if you are taking a GLP-1 medication

Here, we recruited only participants with obesity in the remote study, limiting our results to this specific population