noom compounded semaglutide reddit Extremely disappointing experience : r/Noom Weight-loss company Noom pivots to

Ann Rheum Dis 2026

GLP-1 and amylin-mediated reductions in food intake produce weight loss that includes both fat and lean mass, with the ratio dependent on protein intake, physical activity, and the magnitude of caloric deficit

In a 2-year CV outcomes trial with semaglutide injection involving patients with type 2 diabetes mellitus and high CV risk, diabetic retinopathy complications (which was a 4-component adjudicated endpoint) occurred in patients treated with semaglutide injection (3%) compared to placebo (1.8%)

Most patients starting with normal b12 levels and no significant risk factors do not require supplementation

Maintenance : Once youve achieved your goal, the treated fat cells are gone for good (barring significant weight gain)