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Meanwhile, oral semaglutide has shown cardiovascular safety, with outcome data continuing to evolve

When adding tirzepatide to existing therapy, particularly insulin or sulfonylureas, dose reductions of these agents may be necessary to minimize hypoglycemia risk

Recent advances in incretin-based therapy for MASLD: From single to dual or triple incretin receptor agonists

We acknowledge that the intervention is complex, likely to require at least 10 years of intervention for the endpoint of cancer incidence, and would include behavioural strategies to supplement the chemoprevention during weight loss intervention and maintenance
