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Brain GLP-1 and insulin sensitivity
Administration of exendin-4 into the shell of the NAcc decreases sucrose reward behavior in the progressive ratio (PR) operant conditioning test [701]
In December 2014, they published a paper in Nature Medicine, showing that the triple agonists weight loss effects in mice exceeded those of the dual agonists
Cardiovascular risk reduction throughout GLP-1 receptor agonist and SGLT2 inhibitor modulation of epicardial fat
Retatrutide decreased HbA1c by 2.02% in a phase II clinical trial, while dulaglutide 1.5 mg decreased HbA1c by 1.14% and a placebo decreased it by 0.01% [109]
