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Patients with obesity and/or T2D often experience a decline in SKM coupled with functional deterioration and muscle atrophy, a condition called sarcopenic obesity (SOB) [170]

He stated, Semaglutide 2.4 mg not only reduces the first event risk but also lowers the cumulative cardiovascular burden making it a foundational therapy for secondary prevention in obesity-related cardiovascular disease Vince Lamanna, President of Novo Nordisk Canada, commented that these results expand the meaning of cardiovascular care by integrating obesity treatment as a proven strategy to prevent future events. He highlighted that Health Canadas decision to approve semaglutide 2.4 mg for patients with established CVD and overweight or obesity was the first global regulatory recognition of obesity therapy as a cardiovascular indication

[DOI] [PubMed] [Google Scholar] 29.Gil-Lozano M., Roman-Prez M., Outeirio-Iglesias V., Vigo E., Gonzlez-Matas L.C., Brubaker P.L., Mallo F

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SOUL was a randomized, double blind, parallel-group, placebo-controlled superiority trial that enrolled 9,650 adults with T2DM who had established atherosclerotic cardiovascular disease (ASCVD), chronic kidney disease (CKD), or both, to receive a maximum daily dose of 14 mg oral semaglutide or placebo