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Adams TD, Gress RE, Smith SC, Halverson RC, Simper SC, Rosamond WD, et al
This matters practically: the compound is not simply "wearing off and restoring" each week
Furthermore, these central effects may involve recruitment of pathways that are normally involved in stress and immune regulation, including adrenergic and opioid signaling and blocking either signaling pathway in rodent models again blunts the immunosuppressive effects of GLP-1RA, but this remains an area of active research as it whether this is also the case in humans
Efficacy and safety of GLP-1 agonists in Parkinsons disease: A systematic review and meta-analysis of randomized controlled trials
