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Elevated levels of IGF-2R/M6PR and lysosomal enzymes were also observed in the hippocampus and frontal cortex of APP and APP/PS1 transgenic AD mice, similar to findings in humans [223]

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However, that doesnt mean you shouldnt still be mindful of your calorie intake

They had lower fasting glucose and HbA1c, which was more common in those who lost more weight
