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Clinical data shows tirzepatide delivers 20% mean weight loss at 72 weeks compared to semaglutide's 14%

Tirzepatide has shown sustained safety in clinical trials lasting over two years, with ongoing research supporting extended use for chronic weight management

However, as patients with heart failure, AngII level is elevated and can cause weight loss/cachexia, the usage of incretin analogues to treat non-obese heart failure patients should be considered

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