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- **Curb appetite:** Helping individuals feel full, potentially leading to reduced food intake

Each has demonstrated the potential to emerge as either a Best-in-Class or First-in-Class treatment in the obesity field.The ADA 2025 presentations will cover: Phase 1 Trial Results for HM15275, Robust anti-obesity effect and mechanistic insights of HM15275 in animal models of obesity, Mechanistic insights into HM15275s improved quality of weight loss compared to tirzepatide (Zepbound), Weight loss and differentiated body composition improvement effects of HM17321, Glycemic control improvement observed with HM17321, and Synergistic effects on body composition improvement when combining HM15275 and HM17321A large delegation from Hanmis R&D Center will attend ADA 2025 to present poster sessions showcasing the companys novel therapeutic approaches in obesity treatment and to explore potential collaborations with leading global pharmaceutical companies. HM15275: Next-Generation Triple Agonist Targeting Quantity and Quality of Weight LossHM15275 is engineered to optimize the activity balance of GLP-1, GIP, and glucagon (GCG) receptors, delivering targeted obesity treatment while also addressing comorbid metabolic conditions such as diabetes, cardiovascular, and renal disease

GLP-1 receptor agonist medications are widely used for weight management and diabetes, but understanding pancreatitis risk is essential

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In this Review, the authors discuss neuromodulation therapies in relation to current knowledge of the nerve circuitry, provide insights into possible mechanisms and explore reasons for limited success and how effectiveness might be improved.