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Lipophilic compounds can become trapped in the mucus rather than diffusing through to the epithelium, reducing absorption efficiency
Effects of Onceweekly Semaglutide on Appetite, Energy Intake, Control of Eating, Food Preference and Body Weight in Subjects With Obesity
Christensen M, Vedtofte L, Holst JJ, et al
Some people find that side effects lessen over time with dose adjustments, but not everyone tolerates the oral medication well
