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Tirzepatide injections help millions manage weight by activating dual GLP-1 and GIP receptors in the brain, but some patients experience localized itching at the injection site
BAs activate the nuclear farnesoid X receptor (FXR) and Takeda G protein-coupled receptor 5 (TGR5), and regulate the systemic metabolism of lipids, cholesterol, and glucose, as well as energy and immune homeostasis [1]

There is some intriguing evidence that GLP-1 may actually reduce bloating in the long run by improving gut transit regularity and reducing intestinal inflammation

13 A 200 ml glass of milk and one egg take most adults to around half the daily amount, and a portion of white fish once or twice a week covers the rest

Recognising the heterogeneity of obesity: There is a growing understanding among healthcare stakeholders that a one-dimensional view of obesity solely defined by BMI is grossly inadequate to capture the complexity of its varied manifestations (see Figure 2)
