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M., de Barsy, M., Loumaye, A., Hermans, M

Orum Therapeutics is attempting to overcome this challenge through DACs, which use antibody-mediated delivery to selectively target vulnerable cell populations
Clinical trials show appetite hormones (GLP-1, PYY, GIP) return toward baseline within weeks of stopping medication, increasing hunger signals and food cravings significantly

The drug works by activating both GIP and GLP-1 receptors, a dual mechanism that reduces appetite, slows gastric emptying, improves insulin sensitivity, and enhances fat metabolism

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