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doi: 10.1210/en.2010-0289 [DOI] [PMC free article] [PubMed] [Google Scholar] 43.Knauf C, Cani PD, Ait-Belgnaoui A, et al

Given the divergent outcomes of these studies, the efficacies of GLP-1R agonists for opioid-related responses need to be investigated in greater detail

Safety and Efficacy of the New, Oral, Small-Molecule, GLP-1 Receptor Agonists Orforglipron and Danuglipron for the Treatment of Type 2 Diabetes and Obesity: Systematic Review and Meta-Analysis of Randomized Controlled Trials

Albiglutide Harmony outcomes was a double-blind trial that included a total of 9,463 T2D participants of 40 years of age and a history of CVD, who were allocated to an albiglutide (3050 mg weekly) group or placebo group ( Renoprotection of GLP-1RAs is Largely Dependent on Reduction of Albuminuria As described above, GLP-1RAs have no clinically important effect on eGFR and hard renal endpoints

77 A meta-analysis of 76 RCTs, involving over 100,000 adults with overweight, obesity, or type 2 diabetes found that GLP-1 RA treatment, compared to placebo or other active comparators, was associated with a modestly elevated risk of cholelithiasis (RR: 1.27, 95% CI 1.10, 1.47), cholecystitis (RR: 1.36, 95% CI 1.14, 1.62), and overall biliary disease (RR: 1.55, 95% CI 1.08, 2.22), corresponding to an absolute increase of approximately 27 events per 10,000 patients per year