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What is more, no clear trend for a change in pharmacokinetics was evident across groups with increasing renal dysfunction 12 that allowed us to administer the same dose of the drug and the same blood sampling time points in patients with different degree of renal impairment who were included in our study

They were encouraged by the fact glucagon was proven to be the most potent substance then known to increase the secretion of insulin

Brain Res (2012) 1473:20413

Some clinicians manage discontinuation by gradually tapering the dose rather than stopping abruptly, and others transition patients to phentermine or other medications to blunt the regain

doi: 10.1111/j.1464-5491.2009.02666.x [DOI] [PMC free article] [PubMed] [Google Scholar] 220
