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14 Obesity can also impact the pharmacokinetics of therapies through changes to volume of distribution and drug clearance, 15 and may negatively alter the efficacy of therapies used to treat IBD

Some meds carry bigger riskseither due to side effects, dependency, or long-term complications

Type I cells seem to have glia like function as they express several ion channels (inward rectifying K+ channel [ROMK], glutamate-aspartate transporter [GLAST], ENaC) which are supposed to clear ion currents [222335]

As of May 2026, FDA has also proposed excluding semaglutide, tirzepatide, and liraglutide from the 503B Bulks List, after stating that it did not identify a clinical need for outsourcing facilities to compound these drugs from bulk substances when FDA-approved versions are available