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As a result, interpretations regarding skeletal muscle preservation or loss must be made with caution, particularly in the absence of direct assessments of muscle strength or function

In addition to being used for clinical diagnosis (diagnostic biomarkers), determination of clinical trial eligibility (screening biomarkers), and guiding treatment decisions (prognostic biomarkers), biomarkers can also be used to demonstrate target engagement and to assess the response to an intervention (response biomarkers) (Cummings, 2019
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