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PLoS ONE 2016, 11 (7), e0159782

The FDA boxed warning specifically contraindicates certain GLP-1 receptor agonists in patients with a personal or family history of medullary thyroid carcinoma (MTC) or in patients with multiple endocrine neoplasia syndrome type 2 (MEN 2)

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The caloric deficit created by retatrutide appetite suppression is proportionally larger for someone who exercises regularly

A meta-analysis in 2023 examined 93 clinical trials from ClinicalTrials.gov that compared GLP-1RAs direct or indirect impact on DR with placebo, insulin, or oral antidiabetic medications (Kapoor et al., 2023)