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13 Naloxone challenge: a trial dose of 0.4 mg IV should be given, and the patient observed for signs of withdrawal

however, according to Stanford Medicines blog Scope, its a warning sign if the changes are fast, but if they happen gradually, theres nothing to worry about

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383 As of early 2022, setmelanotide is not approved for the treatment of obesity in individuals who do not have these genetic variants

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