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Weight Loss Efficacy (Phase 2, 48 Weeks) * Retatrutide: Mean body weight reduction up to 24.2% * Eloralintide: Mean body weight reduction up to 20.1% Both agents place themselves among the most potent obesity therapies currently in clinical development.

Conclusions Small increases in heart rate were associated with exenatide QW, exenatide BID, and liraglutide treatments but reverted to baseline after discontinuation