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Crump, R

Although class effects were observed, variations in molecular structure, receptor affinity, and pharmacokinetics may contribute to differential outcomes among GLP-1 RAs

Curr Med Res Opin 2009

Negative energy balance and weight loss can activate the hypothalamic-pituitary-adrenal axis, elevating cortisol levels

For tirzepatide, it ranges from 5 mg to 15 mg weekly depending on individual response and tolerance
