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Our Roots Our story begins with a seed planted by my grandmother, Helen Lane

The investigator decided to withdraw the participant from the study prior to planned IcoSema dosing in the third treatment period

Common First-Dose Experiences and What Is Normal Mild nausea is reported by approximately 25% to 35% of patients starting semaglutide, typically appearing within the first 24 to 72 hours and resolving within days as your body adapts

Weeks 1-4: Minimal change (2-5 lbs possible) Weeks 5-12: Steady loss begins (8-15 lbs cumulative) Weeks 13-24: Acceleration phase (15-25 lbs cumulative) Weeks 25-48: Continued progress (30-45 lbs cumulative) Week 48+: Maintenance phase begins Weeks 12-24 typically represent the fastest weight loss period

Retatrutide (LY-3437943) Clinical Trial Data