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This underscores the importance of careful glucose monitoring if pregnancy occurs on or shortly after GLP-1s

GLP-1 agonists have also shown strong efficacy in clinical trials, with patients achieving an average weight loss of 15-25%, further promoting rapid adoption

For those just starting a tirzepatide protocol, the tirzepatide reconstitution guide and injection site guidance ensure proper preparation and administration

However, in a sensitivity analysis of the REWIND study with dulaglutide, the relative risk reduction for a 40% or 50% decrease in eGFR was 30% and 44%, both significant, in the dulaglutide group compared to placebo, respectively.92 This lower risk of developing macroalbuminuria was also confirmed in an exploratory analysis of the ELIXA (lixisenatide) study.93 In the EXSCEL study (exenatide LAR), renal episodes were analyzed as additional microvascular episodes, and no differences were observed in the risk of episodes related to decreased eGFR, but differences were observed in the composite episode, which included decreased eGFR and macroalbuminuria, although only after adjustment94 (Table 2)

Figure 34: Photograph of Thornberry and Weber, 2017, credit: Chemical Heritage Foundation
