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An ongoing interventional, single-arm, open-label trial (Dapagut study, NCT05965440) is evaluating the effects of dapagliflozin on gut microbiota composition and microbiota-derived metabolites over 12 weeks in non-diabetic adults with CKD
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This shifts fat storage patterns back toward a healthier distribution, improves sleep, stabilizes mood, and, critically, restores GLP-1 receptor sensitivity in the brain
