case report aspiration during anesthesia glp-1 receptor agonist 2023 Perioperative management of patients taking glucagon-like peptide 1 agonists: Society for Perioperative Assessment and Quality Improvement (SPAQI) multidisciplinary consensus statement MHRA warns of pulmonary aspiration

1 Type 2 diabetes mellitus (T2DM) accounts for roughly 90% to 95% of all diagnosed cases of diabetes in the U.S

Industry reports project ~13% annual growth in the GLP-1 peptide CDMO market through 2034 ( [13] )

Just how much of a challenge this posed can be gauged from the fact that Mutt's group needed 10km of porcine small intestine to obtain about 1mg of pure secretin (Rehfeld 2012)

Therefore, issues exist with drug compliance, and the substantial food-drug interactions may potentially generate inconsistent effects in the real-world setting

Nevertheless, the search for orally administrable compounds that retain the impressive properties of GLP-1 receptor agonists persisted (Table 1)