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GLP-1 receptor agonist (GLP-1RA)

Availability timelines are expected in 2025 to 2026 pending trial results and regulatory review

These compounds reduce central neuroinflammation by lowering interleukin (IL)-1, IL-6, and tumor necrosis factor-alpha (TNF-), and limiting oxidative stress ( On the other side, current trends in precision psychiatry aim to classify subpopulations of patients with inflammatory depression, characterized by elevated markers of inflammation, increased glucose and lipid levels, neurovegetative symptoms, anxiety or irritability, and suicidal ideation (Wessa et al., 2026)

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(The mast cell paper mentioned several obese patients who tolerated the standard dose quite well