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Comp Biochem Physiol B Biochem Mol Biol 121(1):4956 Mentlein R, Gallwitz B, Schmidt WE (1993) Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide- 1(736)amide, peptide histidine methionine and is responsible for their degradation in human serum

These peptides enhance each other without competition

PIONEER 4 PIONEER 4, was a 52-week, randomized (2:2:1), controlled, double-blind trial that assessed the efficacy and safety of oral semaglutide 14 mg compared with subcutaneous liraglutide 1.8 mg or placebo in 711 patients (75 patients from Japan) with type 2 diabetes on a stable dose of metformin with or without a sodium glucose cotransporter protein 2 inhibitor [48]