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For optimal hydration, stick with plain water or add natural flavor enhancers like lemon, cucumber, or electrolyte supplements

It can enhance mitochondrial biogenesis

2015;191:A4144 Blackman A, Foster GD, Zammit G, et al

NIBS techniques, mainly rTMS and tDCS, show modest antidepressant effects in bipolar depression, but evidence is more limited compared to disorders such as MDD.[243] Available evidence supports NIBS as an adjunctive treatment for bipolar depression.[243] A meta-analysis showed that high-frequency (HF) rTMS to the left dorsolateral prefrontal cortex (DLPFC) was superior to sham rTMS in acute bipolar depression.[244] No additional risk of a switch to mania was noted

GLP-1 and GIP are incretin hormones that stimulate insulin secretion after an oral glucose load by binding GLP-1R, but both are rapidly inactivated by the enzyme dipeptidyl peptidase-4 (DPP-4)