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Additionally, the cardiac magnetic resonance substudy of the SUMMIT trial revealed that compared with placebo, tirzepatide treatment of obese HFpEF patients reduced the LV mass and paracardial adipose tissue volume, with the changes in the LV mass paralleling the degree of weight loss [166]

The explanatory variables in the model were randomized treatment (semaglutide or comparator), baseline CV risk score (from the CV risk prediction model derived from the LEADER data as described above) and the interaction between treatment and CV risk score

One serious but rare side effect is lactic acidosis, especially in patients with kidney dysfunction