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Description
Hyperinsulinemia and insulin-like growth factor signaling promote epithelial proliferation, inhibit apoptosis, and foster a pro-inflammatory microenvironment within the colon

The most important factor is adherencechoosing a time that fits naturally into daily routines maximises treatment compliance and therapeutic benefit

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These timelines can shift based on trial results and regulatory priorities

Geriatr Gerontol Int 19(12):12891290
