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Its pathogenesis involves a dysfunctional immune response whereby the immune system erroneously attacks synovial tissue[17]

This shift toward a higher serotonin-to-dopamine ratio can result in a subtle blunting of the reward response

So the research that we are doing now is if we can add an amylin agonist on top of a GLP-1 and if that combination does better than the GLP-1 alone, Koren said

The most common side effects are acid reflux, constipation, fatigue, headaches, indigestion, mild nausea, and vomiting, which Saleh says are often eliminated or lessened as the medication stays in the body and you shift your lifestyle and eating habits. To minimize these side effects, avoid foods that are spicy or high in fat, and eat smaller, more frequent meals

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