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When to Seek Medical Support and Personalized Dose Management Contact your healthcare provider if diarrhea persists beyond 12 weeks of stable dosing, occurs multiple times daily with severe urgency, causes dehydration (dark urine, dizziness, extreme thirst), or contains blood or mucus

En los casos en los que se deba sustituir el tratamiento con un aGLP-1 de administracin semanal por una de estas alternativas de administracin diaria, se deben tener en cuenta las siguientes consideraciones: Se debe comenzar a administrar el nuevo tratamiento una semana despus de la ltima dosis Si el tratamiento con aGLP-1 ya estaba establecido, es posible comenzar con la dosis de mantenimiento del nuevo medicamento, sin necesidad de utilizar las dosis de inicio Es recomendable un control glucmico ms estrecho durante las primeras semanas tras la sustitucin Tabla 2